MoA : IL-4 is secreted from Th2 cells. FURESTEM-AD® Inj. is stimulated by IL-4. Stimulated FURESTEM-AD® Inj. secretes TGF-β1. TGF-β1 suppresses expression of FcεR1 receptor (during maturation of mast cells). FURESTEM-AD® Inj. secretes PGE2. PGE2 suppresses degranulation of mast cells. FURESTEM-AD® Inj. inhibits each step of mast cell activation and degranulation through the secretions of TGF-β1 & PGE2.